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Modular design of nanobody-drug conjugates for targeted-delivery of platinum anticancer drugs with an MRI contrast agent.

Author information

Affiliations

  • 1. CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
      Authors
    • Huang H 1
    (1 author)

ORCIDs linked to this article

Chemical Communications (Cambridge, England), 01 Apr 2019, 55(35):5175-5178
https://doi.org/10.1039/c9cc01391a PMID: 30984937 

Abstract 

A multifunctional nanobody-drug conjugate (NDC) was constructed in this work for the targeted delivery of a platinum prodrug and an MRI contrast agent. The NDC can be specifically internalized into EGFR positive cancer cells, resulting in higher therapeutic effect and lower side-effects relative to cisplatin. The Gd-binding domain enables the in situ detection of the drug distribution in vivo.

Full text links 

Read article at publisher's site: https://doi.org/10.1039/c9cc01391a

References 

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Funding 

Funders who supported this work.

National Natural Science Foundation of China (2)