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Survival and Migration of Rat Olfactory Ensheathing Cells after Transplantation into Posttraumatic Cysts in the Spinal Cord.

Author information

Affiliations

  • 1. Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
      Authors
    • Voronova AD 1, 2
    • Valikhov MP 1
    • Stepanova OV 1
    • Mel'nikov PA 1
    • Chadin AV 1
    • Chekhonin VP 1, 2
    (6 authors)
  • 2. Department of Medical Nanobiotechnologies, Medical and Biological Faculty, N. I. Pirogov National Research Medical University, Moscow, Russia.
      Authors
    • Voronova AD 1, 2
    • Sidoruk KN 2
    • Semkina AS 2
    • Abakumov MA 2
    • Chekhonin VP 1, 2
    (5 authors)
  • 3. University Clinical Hospital No. 1, I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
      Authors
    • Reshetov IV 3
    (1 author)

ORCIDs linked to this article

Bulletin of Experimental Biology and Medicine, 12 Nov 2018, 166(1):118-123
https://doi.org/10.1007/s10517-018-4299-z PMID: 30417294 

Abstract 

We studied survival of rat ensheathing cells after transplantation into experimental posttraumatic cysts. These cells were prepared according to our original protocol, labeled with intravital membrane dye PKH26, and transplanted into posttraumatic cysts of the spinal cord. The presence of cysts was verified by magnetic resonance imaging. Olfactory ensheathing cells were detected in the spinal cord by the immunofluorescence method. It was shown that rat olfactory ensheathing cells survived in the spinal cord over 4 weeks and their migration was observed. High survival rate and the possibility of obtaining olfactory ensheathing cells from the olfactory mucosa of patients for creation of an autologous preparation allow considering them as very promising material for the treatment of patients with posttraumatic cysts of the spinal cord.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/s10517-018-4299-z

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