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Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.

Author information

Affiliations

  • 1. Department of Clinical Neuroscience and Cambridge Stem Cell Institute, Forvie Site, Cambridge CB2 0PY, UK.
      Authors
    • Barker RA 1
    (1 author)
  • 2. Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden.
      Authors
    • Parmar M 2
    (1 author)
  • 3. Developmental Biology, The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA.
      Authors
    • Studer L 3
    (1 author)
  • 4. Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 606-8507, Kyoto, Japan.
      Authors
    • Takahashi J 4
    (1 author)

ORCIDs linked to this article

Cell Stem Cell, 01 Nov 2017, 21(5):569-573
https://doi.org/10.1016/j.stem.2017.09.014 PMID: 29100010 

Abstract 

Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations from our recent fourth GForce-PD meeting.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.stem.2017.09.014

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S193459091730382X/pdfUnpaywall

Citations & impact 

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Funding 

Funders who supported this work.

Cure Parkinson’s Trust, Rosetrees Trust

    EU (1)

    Japan Agency for Medical Research and Development

      MRC-WT

        Medical Research Council (1)

        NYSTEM

          National Institute for Health Research (NIHR) (1)

          Swedish Research Council

            The Swedish Brain Foundation

              The Swedish Parkinson Foundation

                UK RMP Pluripotent stem cell hub