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Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

Author information

Affiliations

  • 1. Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany.
      Authors
    • Klingenberg M 1
    (1 author)
  • 2. Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
      Authors
    • Matsuda A 2
    • Patel T 2
    (2 authors)
  • 3. Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; Division of Cancer Research, Dept. of Thoracic Surgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany.
      Authors
    • Diederichs S 3
    (1 author)

ORCIDs linked to this article

Journal of Hepatology, 22 Apr 2017, 67(3):603-618
https://doi.org/10.1016/j.jhep.2017.04.009 PMID: 28438689 

Review

Abstract 

The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.jhep.2017.04.009

Read article for free, from open access legal sources, via Unpaywall: http://www.journal-of-hepatology.eu/article/S0168827817302507/pdfUnpaywall

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