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High TUG1 expression is associated with chemotherapy resistance and poor prognosis in esophageal squamous cell carcinoma.

Author information

Affiliations

  • 1. Department of Anesthesiology, Taizhou People's Hospital, Taizhou, Jiangsu, China.
      Authors
    • Jiang L 1
    • Sun C 1
    • Ren Z 1
    (3 authors)
  • 2. Department of Pathology, Yangzhou University School of Medicine, Yangzhou, Jiangsu, China.
      Authors
    • Wang W 2
    • Li G 2
    (2 authors)
  • 3. Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai, Shanghai, China.
      Authors
    • Sheng H 3
    • Gao H 3
    (2 authors)
  • 4. Department of Pathology, Ruijing Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 00032, China.
      Authors
    • Wang C 4
    (1 author)
  • 5. Department of Pathology, Taizhou People's Hospital, Taizhou, 225300, Jiangsu, China.
      Authors
    • Yu H 5
    (1 author)

Cancer Chemotherapy and Pharmacology, 21 Jun 2016, 78(2):333-339
https://doi.org/10.1007/s00280-016-3066-y PMID: 27329359 

Abstract 

Purpose

Long noncoding RNAs (lncRNAs) play critical roles in diverse biological processes such as tumorigenesis and metastasis. Taurine upregulated gene 1 (TUG1) is a cancer-related lncRNA that is associated with chromatin-modifying complexes and plays an important role in gene regulation. In this study, we determined the expression patterns of TUG1 in esophageal squamous cell carcinoma (ESCC) and evaluated its clinical significance.

Methods

The expression level of TUG1 was examined in 218 pairs of ESCC and adjacent non-cancerous tissues by using quantitative real-time polymerase chain reaction. The relationship between TUG1 expression and clinical features and prognosis was statistically analyzed.

Results

The expression level of TUG1 was significantly upregulated in ESCC tissues compared with paired adjacent normal tissues. High TUG1 expression was significantly correlated with chemotherapy resistance. Survival analysis showed that patients with high TUG1 expression had poor prognosis, especially for cases with well and moderate differentiation, ulcerative type, smaller size, and chemotherapy-sensitive tumors.

Conclusions

Our findings suggest that elevated TUG1 expression is related to chemotherapy resistance and may help predict a poor prognostic outcome of ESCC. TUG1 may provide a potential therapeutic target for ESCC.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/s00280-016-3066-y

References 

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Funding 

Funders who supported this work.

Taizhou Society Development Project (1)

The 12th five –year plan key project of science and technology (1)

The 333 project of scientific research project Foundation (1)