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Mechanisms of cancer dissemination along nerves.

Author information

Affiliations

  • 1. Laboratory for Applied Cancer Research, Department of Otolaryngology Head and Neck Surgery, Head and Neck Center, Rambam Healthcare Campus, Clinical Research Institute at Rambam, Rappaport Institute of Medicine and Research, The Technion-Israel Institute of Technology, Haalia Street No. 8, Haifa, Israel.
      Authors
    • Amit M 1
    • Na'ara S 1
    • Gil Z 1
    (3 authors)

Nature reviews. Cancer, 06 May 2016, 16(6):399-408
https://doi.org/10.1038/nrc.2016.38 PMID: 27150016 

Review

Abstract 

The local extension of cancer cells along nerves is a frequent clinical finding for various tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; however, recent animal models and human studies have revealed that cancer cells have an innate ability to actively migrate along axons in a mechanism called neural tracking. The tendency of cancer cells to track along nerves is supported by various cell types in the perineural niche that secrete multiple growth factors and chemokines. We propose that the perineural niche should be considered part of the tumour microenvironment, describe the molecular cues that facilitate neural tracking and suggest methods for its inhibition.

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Read article at publisher's site: https://doi.org/10.1038/nrc.2016.38

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