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Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects.

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Affiliations

  • 1. Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, Villejuif, 94805, France; Institut National de la Santé Et de la Recherche Medicale (INSERM), U1015, GRCC, Villejuif, 94805, France; University of Paris-Saclay, Kremlin Bicêtre, 94270, France.
      Authors
    • Daillère R 1
    • Vétizou M 1
    • Poirier-Colame V 1
    • Routy B 1
    • Jacquelot N 1
    (5 authors)
  • 2. University Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL, Centre d'Infection et d'Immunité de Lille, 59000 Lille, France.
      Authors
    • Waldschmitt N 2
    • Chamaillard M 2
    (2 authors)
  • 3. Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, Villejuif, 94805, France; Institut National de la Santé Et de la Recherche Medicale (INSERM), U1015, GRCC, Villejuif, 94805, France.
      Authors
    • Yamazaki T 3
    (1 author)
  • 4. Université de Caen Basse-Normandie, EA4655 U2RM (Équipe Antibio-Résistance), Caen, 14033, France; CHU de Caen, Service de Microbiologie, Caen, 14033, France.
      Authors
    • Isnard C 4
    (1 author)
  • 5. Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, Villejuif, 94805, France; Institut National de la Santé Et de la Recherche Medicale (INSERM), U1015, GRCC, Villejuif, 94805, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, 94805, France.
      Authors
    • Duong CPM 5
    • Flament C 5
    • Roberti MP 5
    • Becharef S 5
    • Rusakiewicz S 5
    (5 authors)
    • Show all (22)

ORCIDs linked to this article

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Immunity, 04 Oct 2016, 45(4):931-943
https://doi.org/10.1016/j.immuni.2016.09.009 PMID: 27717798 

A comment on this article appears in "Two Bugs a NOD Away from Improving Cancer Therapy Efficacy." Immunity. 2016 Oct 18;45(4):714-716.

Abstract 

The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are involved in tumor immunosurveillance, and their mechanism of action are unclear. Here, we identified two bacterial species, Enterococcus hirae and Barnesiella intestinihominis that are involved during CTX therapy. Whereas E. hirae translocated from the small intestine to secondary lymphoid organs and increased the intratumoral CD8/Treg ratio, B. intestinihominis accumulated in the colon and promoted the infiltration of IFN-γ-producing γδT cells in cancer lesions. The immune sensor, NOD2, limited CTX-induced cancer immunosurveillance and the bioactivity of these microbes. Finally, E. hirae and B. intestinihominis specific-memory Th1 cell immune responses selectively predicted longer progression-free survival in advanced lung and ovarian cancer patients treated with chemo-immunotherapy. Altogether, E. hirae and B. intestinihominis represent valuable "oncomicrobiotics" ameliorating the efficacy of the most common alkylating immunomodulatory compound.

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Read article at publisher's site: https://doi.org/10.1016/j.immuni.2016.09.009

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S1074761316303788/pdfUnpaywall

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NCI NIH HHS (1)