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Conservation of mitotic controls in fission and budding yeasts.

Author information

Affiliations

  • 1. Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.
      Authors
    • Russell P 1
    (1 author)

ORCIDs linked to this article

Cell, 01 Apr 1989, 57(2):295-303
https://doi.org/10.1016/0092-8674(89)90967-7 PMID: 2649252 

Abstract 

In fission yeast, the initiation of mitosis is regulated by a control network that integrates the opposing activities of mitotic inducers and inhibitors. To evaluate whether this control system is likely to be conserved among eukaryotes, we have investigated whether a similar mitotic control operates in the distantly related budding yeast S. cerevisiae. We have found that the protein kinase encoded by the mitotic inhibitor gene wee1+ of fission yeast, which acts to delay mitosis, is able also to delay the initiation of mitosis when expressed in S. cerevisiae. The wee1+ activity is counteracted in S. cerevisiae by the gene product of MIH1, a newly identified gene capable of encoding a protein of MW 54,000, which is a structural and functional homolog of the cdc25+ mitotic inducer of fission yeast. Expression of wee1+ in a mih1- strain prevents the initiation of mitosis. These data indicate that important features of the cdc25+-wee1+ mitotic control network identified in S. pombe are conserved in S. cerevisiae, and therefore are also likely to be generally conserved among eukaryotic organisms.

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Funding 

Funders who supported this work.

NIGMS NIH HHS (2)