Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Impact of prenatal screening and diagnostic testing on trends in Down syndrome births and terminations in Western Australia 1980 to 2013.

Author information

Affiliations

  • 1. Health Policy and Management, School of Public Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
      Authors
    • Maxwell S 1
    • O'Leary P 1
    (2 authors)
  • 2. Telethon Kids Institute, The University of Western Australia, Crawley, WA, Australia.
      Authors
    • Bower C 2
    (1 author)

ORCIDs linked to this article

Prenatal Diagnosis, 19 Nov 2015, 35(13):1324-1330
https://doi.org/10.1002/pd.4698 PMID: 26411476 

Abstract 

Objective

To assess how prenatal screening and diagnostic testing have impacted the diagnosis, termination and birth prevalence of Down syndrome in Western Australia (1980-2013).

Method

We analysed trends in termination rates and birth prevalence of Down syndrome using aggregated data (1980-2013). We modelled the expected live-birth rate and prevalence of Down syndrome and compared different eras of screening and diagnosis with respect to the impact on live-birth rate and prevalence of Down syndrome.

Results

Between 1980 and 2013, the rate of Down syndrome pregnancies increased, corresponding to a greater proportion of babies born to older women. Following the introduction of screening in 1994, the rate of live-born infants with Down syndrome reduced significantly (p = 0.001). The rate of terminations of pregnancy for Down syndrome remained stable over this period. In the absence of termination, the Down syndrome live-birth rate would have risen from 1.1 per 1000 to 2.17 per 1000 between 1980 and 2013.

Conclusion

Prenatal testing in Western Australia has reduced the birth prevalence of Down syndrome despite an increased rate of Down syndrome pregnancies. Most women for whom a prenatal diagnosis of fetal Down syndrome is made, chose to terminate the pregnancy (93%), and this proportion has not changed over the study period.

Full text links 

Read article at publisher's site: https://doi.org/10.1002/pd.4698

References 

Articles referenced by this article (26)

Show 10 more references (10 of 26)

Citations & impact 

Impact metrics

20
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/17183851
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/17183851

Article citations

Go to all (20) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.