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Chronic kidney disease and premature ageing.

Author information

Affiliations

  • 1. Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastrich, Netherlands.
      Authors
    • Kooman JP 1
    (1 author)
  • 2. Renal Research Institute, 315 East 62nd Street, 4th floor, NY 10065, New York, USA.
      Authors
    • Kotanko P 2
    (1 author)
  • 3. Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastrich, Netherlands.
      Authors
    • Schols AM 3
    (1 author)
  • 4. Institute of Cancer Sciences, Wolfson Wohl Translational Research Centre, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, UK.
      Authors
    • Shiels PG 4
    (1 author)
  • 5. Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Huddinge, Karolinska Institutet, SE-14157 Stockholm, Sweden.
      Authors
    • Stenvinkel P 5
    (1 author)

ORCIDs linked to this article

Nature reviews. Nephrology, 07 Oct 2014, 10(12):732-742
https://doi.org/10.1038/nrneph.2014.185 PMID: 25287433 

Review

Abstract 

Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and rheumatoid arthritis. The most apparent similarity is premature ageing, involving accelerated vascular disease and muscle wasting. We propose that in addition to a sedentary lifestyle and psychosocial and socioeconomic determinants, four major disease-induced mechanisms underlie premature ageing in CKD: an increase in allostatic load, activation of the 'stress resistance response', activation of age-promoting mechanisms and impairment of anti-ageing pathways. The most effective current interventions to modulate premature ageing-treatment of the underlying disease, optimal nutrition, correction of the internal environment and exercise training-reduce systemic inflammation and oxidative stress and induce muscle anabolism. Deeper mechanistic insight into the phenomena of premature ageing as well as early diagnosis of CKD might improve the application and efficacy of these interventions and provide novel leads to combat muscle wasting and vascular impairment in chronic diseases.

Full text links 

Read article at publisher's site: https://doi.org/10.1038/nrneph.2014.185

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