Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

T cell exclusion, immune privilege, and the tumor microenvironment.

Author information

Affiliations

  • 1. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
      Authors
    • Joyce JA 1
    (1 author)
  • 2. Cold Spring Harbor Laboratory, New York, NY 11724, USA. Department of Microbiology and Immunology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical School, New York, NY 10065, USA.
      Authors
    • Fearon DT 2
    (1 author)

Science, 01 Apr 2015, 348(6230):74-80
https://doi.org/10.1126/science.aaa6204 PMID: 25838376 

Review

Abstract 

Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific T cells be generated, but also that these T cells physically contact cancer cells. The coexistence in some patients of cancer cells and T cells that recognize them indicates that tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from immune attack. Here, we review the evidence that stromal cells of the tumor microenvironment mediate this restriction by excluding T cells from the vicinity of cancer cells. Overcoming this T cell checkpoint may thus enable optimal immunotherapy.

Full text links 

Read article at publisher's site: https://doi.org/10.1126/science.aaa6204

Read article for free, from open access legal sources, via Unpaywall: https://science.sciencemag.org/content/sci/348/6230/74.full.pdfUnpaywall

References 

Articles referenced by this article (82)

Show 10 more references (10 of 82)

Citations & impact 

Impact metrics

1,183
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/3865810
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/3865810

Article citations

Go to all (1,183) article citations

Other citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

American Cancer Society

    Breast Cancer Research Foundation

      Cancer Research UK (1)

      Center for Metastasis Research at MSKCC

        Cycle for Survival

          National Cancer Institute

            New York State Health Research Science Board