Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs.

Abstract

Microtubules are involved in the transport of vesicles in interphase and of the chromosomes during mitosis. Their arrangement and orientation in the cell are therefore of prime importance and specific patterns are believed to be generated by modulations of the intrinsic dynamic instability of microtubules. Here it is shown that the interphase-metaphase transition of microtubule arrays is under the control of the cdc2 kinase that precisely regulates the dynamics and steady-state length of microtubules.

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References

Articles referenced by this article (48)

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Minimal Mechanisms of Microtubule Length Regulation in Living Cells.
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Measuring Mitotic Spindle and Microtubule Dynamics in Marine Embryos and Non-model Organisms.
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Preparation of Xenopus borealis and Xenopus tropicalis Egg Extracts for Comparative Cell Biology and Evolutionary Studies.
Kitaoka M, Guilloux G, Heald R, Gibeaux R
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Spatial and Temporal Scaling of Microtubules and Mitotic Spindles.
Lacroix B, Dumont J
Cells, 11(2):248, 12 Jan 2022
Cited by: 2 articles | PMID: 35053364 | PMCID: PMC8774166
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Nucleus-Cytoskeleton Crosstalk During Mitotic Entry.
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Front Cell Dev Biol, 9:649899, 18 Mar 2021
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Xenbase is a model organism database, providing bioinformatics resources, as well as genomic and biological data on Xenopus laevis and Xenopus tropicalis frogs.

https://www.xenbase.org/literature/article.do?method=display&articleId=26137

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Abstract

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References

Wilson, E. B. The Sources of Science 30, 45–87 (Johnson Reprint Corporation, 1966).

Inoue, S. J. Cell Biol. 51, 1315–1475 (1981).

Centrioles in the cell cycle. I. Epithelial cells.

Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle.

Bajer, A. & Mole-Bajer, J. Chromosoma 27, 448–484 (1969).

Vandre, D. D., Kronebush, P. & Borisy, G. in Molecular Biology of the Cytoskeleton (eds Borisy, G. G., Cleveland, D. W. & Murphy, D. B.) 3–16 (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1984).

Diffusion coefficient of fluorescein-labeled tubulin in the cytoplasm of embryonic cells of a sea urchin: video image analysis of fluorescence redistribution after photobleaching.

Tubulin dynamics in cultured mammalian cells.

Nicklas, R. B. Adv. Cell Biol. 2, 225–297 (1971).

The formation, structure, and composition of the mammalian kinetochore and kinetochore fiber.

Citations & impact

Impact metrics

Citations of article over time

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Article citations

Minimal Mechanisms of Microtubule Length Regulation in Living Cells.

Measuring Mitotic Spindle and Microtubule Dynamics in Marine Embryos and Non-model Organisms.

Preparation of Xenopus borealis and Xenopus tropicalis Egg Extracts for Comparative Cell Biology and Evolutionary Studies.

Spatial and Temporal Scaling of Microtubules and Mitotic Spindles.

Nucleus-Cytoskeleton Crosstalk During Mitotic Entry.

Data

Data that cites the article

Xenbase is a model organism database, providing bioinformatics resources, as well as genomic and biological data on Xenopus laevis and Xenopus tropicalis frogs.

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Search life-sciences literature (45,100,050 articles, preprints and more)

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs.

Author information

Affiliations

Abstract

Full text links

References

Wilson, E. B. The Sources of Science 30, 45–87 (Johnson Reprint Corporation, 1966).

Inoue, S. J. Cell Biol. 51, 1315–1475 (1981).

Bajer, A. & Mole-Bajer, J. Chromosoma 27, 448–484 (1969).

Vandre, D. D., Kronebush, P. & Borisy, G. in Molecular Biology of the Cytoskeleton (eds Borisy, G. G., Cleveland, D. W. & Murphy, D. B.) 3–16 (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1984).

Nicklas, R. B. Adv. Cell Biol. 2, 225–297 (1971).

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Article citations

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Data that cites the article

Xenbase is a model organism database, providing bioinformatics resources, as well as genomic and biological data on Xenopus laevis and Xenopus tropicalis frogs.

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