Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Forceps minor damage and co-occurrence of depression and fatigue in multiple sclerosis.

Author information

Affiliations

  • 1. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy/Neurocenter of Southern Switzerland, Civic Hospital, Switzerland.
      Authors
    • Gobbi C 1
    • Riccitelli GC 1
    (2 authors)
  • 2. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy/San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy.
      Authors
    • Rocca MA 2
    (1 author)
  • 3. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy.
      Authors
    • Pagani E 3
    (1 author)
  • 4. Neurocenter of Southern Switzerland, Civic Hospital, Switzerland.
      Authors
    • Pravatà E 4
    (1 author)
  • 5. San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy.
      Authors
    • Radaelli M 5
    • Martinelli-Boneschi F 5
    • Comi G 5
    (3 authors)
    • Show all (8)

ORCIDs linked to this article

Show all (9)

Multiple Sclerosis (Houndmills, Basingstoke, England), 16 Apr 2014, 20(12):1633-1640
https://doi.org/10.1177/1352458514530022 PMID: 24740370 

Abstract 

Objective

Using diffusion tensor magnetic resonance imaging (DT MRI), we analyzed the architectural integrity of the brain white matter (WM) from a large cohort of MS patients to identify the structural substrates of the concomitant presence of depression and fatigue.

Methods

Brain dual-echo, 3D T1-weighted and DT MRI scans were acquired from 147 MS patients and 90 gender- and age-matched healthy controls (HCs). Patients were stratified by the presence of depression (92 depressed (D), 55 not depressed (nD)) and fatigue (81 fatigued (F), 66 not fatigued (nF)). Sixty-five patients had co-occurrence of depression and fatigue (DF). Whole-brain voxel-wise comparisons of WM DT MRI abnormalities were performed using tract-based-spatial-statistics (TBSS). Tract-specific analyses were run in brain WM tracts using standard-space templates.

Results

Whole-brain voxel-wise analysis yielded no significant differences between patient subgroups. At tract-specific analysis, DF patients had reduced fractional anisotropy (FA) of the forceps minor. Reduced FA of the right anterior thalamic radiation and right uncinate fasciculus was found in F-MS vs not F-MS patients after correcting for depression. No significant differences were found between D vs not D-MS patients, after correcting for fatigue.

Conclusions

This study provides evidence for partially overlapping damage to frontal and fronto-temporal pathways underlying depression and fatigue in MS.

Full text links 

Read article at publisher's site: https://doi.org/10.1177/1352458514530022

References 

Articles referenced by this article (36)

Show 10 more references (10 of 36)

Citations & impact 

Impact metrics

31
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/2287686
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/2287686

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1177/1352458514530022

Supporting
Mentioning
Contrasting
6
56
0

Article citations

Go to all (31) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.