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Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure.

Author information

Affiliations

  • 1. Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.
      Authors
    • Swirski FK 1
    (1 author)

ORCIDs linked to this article

Science, 01 Jan 2013, 339(6116):161-166
https://doi.org/10.1126/science.1230719 PMID: 23307733 PMCID: PMC3891792

ReviewFree full text in Europe PMC

Abstract 

Cardiovascular diseases claim more lives worldwide than any other. Etiologically, the dominant trajectory involves atherosclerosis, a chronic inflammatory process of lipid-rich lesion growth in the vascular wall that can cause life-threatening myocardial infarction (MI). Those who survive MI can develop congestive heart failure, a chronic condition of inadequate pump activity that is frequently fatal. Leukocytes (white blood cells) are important participants at the various stages of cardiovascular disease progression and complication. This Review will discuss leukocyte function in atherosclerosis, MI, and heart failure.

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Time: 2024/11/20 08:45:20

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Read article at publisher's site: https://doi.org/10.1126/science.1230719

Read article for free, from open access legal sources, via Unpaywall: https://europepmc.org/articles/pmc3891792?pdf=renderUnpaywall

Citations & impact 

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Funding 

Funders who supported this work.

NHLBI NIH HHS (6)