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Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease.

Author information

Affiliations

  • 1. Division of Nephrology and Hypertension, University of California Irvine Medical Center, Suite 400, City Tower, 101 City Drive, Orange, CA, 92868, USA,
      Authors
    • Vaziri ND 1
    (1 author)

Clinical and Experimental Nephrology, 24 Aug 2013, 18(2):265-268
https://doi.org/10.1007/s10157-013-0847-z PMID: 23974528 

Review

Abstract 

Advanced chronic kidney disease (CKD) results in a constellation of dysregulation of lipid metabolism, oxidative stress, and inflammation which are causally interconnected and participate in a vicious cycle. The CKD-associated lipid disorders are marked by impaired clearance of very low density lipoprotein and chylomicrons, hypertriglyceridemia, formation of small dense low-density lipoprotein (LDL), oxidative modification of LDL, intermediate density lipoprotein and chylomicron remnants, and high-density lipoprotein deficiency and dysfunction. This review provides a brief overview of the role of CKD-induced lipid disorders in the pathogenesis of oxidative stress, inflammation, cardiovascular disease, impaired exercise capacity, cachexia and wasting syndrome.

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Read article at publisher's site: https://doi.org/10.1007/s10157-013-0847-z

Read article for free, from open access legal sources, via Unpaywall: https://escholarship.org/content/qt7qc1t62d/qt7qc1t62d.pdf?t=nm3je7Unpaywall

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