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Multifunctional bioactive glass scaffolds coated with layers of poly(D,L-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin.

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Affiliations

  • 1. TECNALIA Health Division and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 20009 San Sebastián, Spain.
      Authors
    • Olalde B 1
    (1 author)

ORCIDs linked to this article

Materials Science & engineering. C, Materials for Biological Applications, 09 May 2013, 33(7):3760-3767
https://doi.org/10.1016/j.msec.2013.05.002 PMID: 23910274 

Abstract 

A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass® derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid.

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Read article at publisher's site: https://doi.org/10.1016/j.msec.2013.05.002

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