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Fe(III) distribution varies substantially within and between atherosclerotic plaques.

Author information

Affiliations

  • 1. Department of Medical and Health Sciences (IMH), Division of Radiological Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
      Authors
    • Gustafsson H 1
    (1 author)

ORCIDs linked to this article

Magnetic Resonance in Medicine, 01 Feb 2014, 71(2):885-892
https://doi.org/10.1002/mrm.24687 PMID: 23447110 

Abstract 

Purpose

Vulnerable atherosclerotic plaques are structurally weak and prone to rupture, presumably due to local oxidative stress. Redox active iron is linked to oxidative stress and the aim of this study was to investigate the distribution of Fe(III) in carotid plaques and its relation to vulnerability for rupture.

Methods

Atherosclerotic plaques from 10 patients (three asymptomatic and seven symptomatic) were investigated. Plaque vulnerability was classified using ultrasound and immunohistochemistry and correlated to Fe(III) measured by electron paramagnetic resonance spectroscopy.

Results

Large intra-plaque Fe(III) variations were found. Plaques from symptomatic patients had a higher Fe(III) concentration as compared with asymptomatic plaques (0.36 ± 0.21 vs. 0.06 ± 0.04 nmol Fe(III)/mg tissue, P < 0.05, in sections adjoining narrowest part of the plaques). All but one plaque from symptomatic patients showed signs of cap rupture. No plaque from asymptomatic patients showed signs of cap rupture. There was a significant increase in cap macrophages in plaques from symptomatic patients compared with asymptomatic patients (31 ± 11% vs. 2.3 ± 2.3%, P < 0.01).

Conclusion

Fe(III) distribution varies substantially within atherosclerotic plaques. Plaques from symptomatic patients had significantly higher concentrations of Fe(III), signs of cap rupture and increased cap macrophage activity.

Full text links 

Read article at publisher's site: https://doi.org/10.1002/mrm.24687

Read article for free, from open access legal sources, via Unpaywall: http://liu.diva-portal.org/smash/get/diva2:651081/FULLTEXT01Unpaywall

Linköping University Digital Archive
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-98001

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Funding 

Funders who supported this work.

The Swedish Research Council (1)

  • Grant ID: 2009-5430; Grant sponsor: Stiftelsen Lars Hiertas Minne; Grant number: FO2009-0345; Grant sponsor: Medical Research Council of Southeast Sweden (FORSS)

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