Regulation of integrin activation.

Abstract

Regulation of cell-cell and cell-matrix interaction is essential for the normal physiology of metazoans and is important in many diseases. Integrin adhesion receptors can rapidly increase their affinity (integrin activation) in response to intracellular signaling events in a process termed inside-out signaling. The transmembrane domains of integrins and their interactions with the membrane are important in inside-out signaling. Moreover, integrin activation is tightly regulated by a complex network of signaling pathways. Here, we review recent progress in understanding how the membrane environment can, in cooperation with integrin-binding proteins, regulate integrin activation.

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Articles referenced by this article (144)

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β2 integrins impose a mechanical checkpoint on macrophage phagocytosis.
Settle AH, Winer BY, de Jesus MM, Seeman L, Wang Z, Chan E, Romin Y, Li Z, Miele MM, Hendrickson RC, Vorselen D, Perry JSA, Huse M
Nat Commun, 15(1):8182, 18 Sep 2024
Cited by: 0 articles | PMID: 39294148 | PMCID: PMC11411054
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Membrane-induced 2D phase separation of the focal adhesion protein talin.
Litschel T, Kelley CF, Cheng X, Babl L, Mizuno N, Case LB, Schwille P
Nat Commun, 15(1):4986, 11 Jun 2024
Cited by: 1 article | PMID: 38862544
Ligand binding initiates single-molecule integrin conformational activation.
Li J, Jo MH, Yan J, Hall T, Lee J, López-Sánchez U, Yan S, Ha T, Springer TA
Cell, 187(12):2990-3005.e17, 20 May 2024
Cited by: 2 articles | PMID: 38772370
Producing highly effective extracellular vesicles using IBAR and talin F3 domain fusion.
Lee J, Lee M, Kim J, Cho EG, Kim C
Anim Cells Syst (Seoul), 28(1):283-293, 18 May 2024
Cited by: 0 articles | PMID: 38770055 | PMCID: PMC11104707
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targets.
Su C, Mo J, Dong S, Liao Z, Zhang B, Zhu P
Cell Commun Signal, 22(1):71, 26 Jan 2024
Cited by: 3 articles | PMID: 38279122 | PMCID: PMC10811905
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The Rat Genome Database (RGD) was established in 1999 and rapidly became the premier site for genetic, genomic, phenotype, and disease-related data generated from rat research. In addition, RGD has expanded to include a large body of structured and standardized data for eight species (rat, mouse, human, chinchilla, bonobo, 13-lined ground squirrel, dog and pig). Much of this data is the result of manual curation work by RGD curators. In other instances, it has been imported into RGD from other databases through custom ELT (Extract, Load and Transform) pipelines giving RGD users integrated access to a wide variety of data to support their research efforts. RGD also offers a growing suite of innovative tools for querying, analyzing and visualizing this data making it a valuable resource for researchers worldwide.

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NHLBI NIH HHS (1)

Grant ID: P01 HL031950
131 publications

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References

The ins and outs of leukocyte integrin signaling.

Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin.

Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography.

Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.

Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells.

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

Determination of the border between the transmembrane and cytoplasmic domains of human integrin subunits.

Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain.

Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets.

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.

Citations & impact

Impact metrics

Citations of article over time

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Article citations

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis.

Membrane-induced 2D phase separation of the focal adhesion protein talin.

Ligand binding initiates single-molecule integrin conformational activation.

Producing highly effective extracellular vesicles using IBAR and talin F3 domain fusion.

Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targets.

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Regulation of integrin activation.

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