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Post-translational modification by SUMO.

Author information

Affiliations

  • 1. Medical Research Council-Centre for Regenerative Medicine, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH164SB, UK.
      Authors
    • Hannoun Z 1
    (1 author)

ORCIDs linked to this article

Toxicology, 30 Jul 2010, 278(3):288-293
https://doi.org/10.1016/j.tox.2010.07.013 PMID: 20674646 

Review

Abstract 

Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle regulation, gene transcription, differentiation and cellular localisation. Therefore, understanding the role of SUMOylation in cell biology may allow the development of more efficient models, important in streamlining the drug discovery process. This review will focus on protein SUMOylation and its role in stem cell and somatic cell biology.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.tox.2010.07.013

Read article for free, from open access legal sources, via Unpaywall: https://www.pure.ed.ac.uk/ws/files/8224963/Hannoun_et_al_2010.pdfUnpaywall

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    Funding 

    Funders who supported this work.

    Cancer Research UK

      Medical Research Council (1)