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Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature.

Author information

Affiliations

  • 1. Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
      Authors
    • Stenman JM 1
    (1 author)

Science, 01 Nov 2008, 322(5905):1247-1250
https://doi.org/10.1126/science.1164594 PMID: 19023080 

A comment on this article appears in "Developmental biology. Brain Wnts for blood vessels." Science. 2008 Nov 21;322(5905):1195-6.

Abstract 

Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly diverse. The central nervous system (CNS) vasculature consists of a tightly sealed endothelium that forms the blood-brain barrier, whereas blood vessels of other organs are more porous. Wnt7a and Wnt7b encode two Wnt ligands produced by the neuroepithelium of the developing CNS coincident with vascular invasion. Using genetic mouse models, we found that these ligands directly target the vascular endothelium and that the CNS uses the canonical Wnt signaling pathway to promote formation and CNS-specific differentiation of the organ's vasculature.

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Read article at publisher's site: https://doi.org/10.1126/science.1164594

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http://www.sciencemag.org/cgi/content/full/322/5905/1247

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http://www.sciencemag.org/cgi/content/abstract/322/5905/1247

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Funding 

Funders who supported this work.

NHLBI NIH HHS (1)

NIDDK NIH HHS (2)