Chromosome crosstalk in three dimensions.

Abstract

The genome forms extensive and dynamic physical interactions with itself in the form of chromosome loops and bridges, thus exploring the three-dimensional space of the nucleus. It is now possible to examine these interactions at the molecular level, and we have gained glimpses of their functional implications. Chromosomal interactions can contribute to the silencing and activation of genes within the three-dimensional context of the nuclear architecture. Technical advances in detecting these interactions contribute to our understanding of the functional organization of the genome, as well as its adaptive plasticity in response to environmental changes during development and disease.

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Abstract

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References

Wilson, E. The Cell in Development and Heredity (Macmillan, 1928).

Transvection effects in Drosophila.

The organization of replication and transcription.

Cell biology: Nuclear order out of chaos.

De novo formation of a subnuclear body.

The epigenetics of rRNA genes: from molecular to chromosome biology.

Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions.

Active genes dynamically colocalize to shared sites of ongoing transcription.

Visualization of focal sites of transcription within human nuclei.

Citations & impact

Impact metrics

Citations of article over time

Article citations

Challenges in Analyzing Functional Epigenetic Data in Perspective of Adolescent Psychiatric Health.

Predict long-range enhancer regulation based on protein-protein interactions between transcription factors.

Modeling and analysis of Hi-C data by HiSIF identifies characteristic promoter-distal loops.

Pericentromere clustering in Tradescantia section Rhoeo involves self-associations of AT- and GC-rich heterochromatin fractions, is developmentally regulated, and increases during differentiation.

Aneuploidy and gene expression: is there dosage compensation?

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Chromosome crosstalk in three dimensions.

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Wilson, E. The Cell in Development and Heredity (Macmillan, 1928).

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