Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa.

Author information

Affiliations

  • 1. Department of Chemistry and Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
      Authors
    • Park J 1
    (1 author)

The Journal of Infectious Diseases, 01 Oct 2008, 198(8):1198-1201
https://doi.org/10.1086/591916 PMID: 18713055 

Abstract 

In Pseudomonas aeruginosa, quorum-sensing (QS) signaling regulates the expression of virulence factors and thus represents an attractive new target for anti-infective therapy. In the present study, we investigated whether solenopsin A, a venom alkaloid from the fire ant, possessed agonistic or antagonistic QS signaling activity in P. aeruginosa. We evaluated the modulation of virulence factor expression and transcriptional levels of QS-regulated genes in P. aeruginosa by solenopsin A and demonstrated that solenopsin A efficiently disrupted QS signaling. Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, restored P. aeruginosa QS signaling, suggesting that solenopsin A targets the C(4)-HSL-dependent rhl QS system.

Full text links 

Read article at publisher's site: https://doi.org/10.1086/591916

Read article for free, from open access legal sources, via Unpaywall: https://academic.oup.com/jid/article-pdf/198/8/1198/18055677/198-8-1198.pdfUnpaywall

References 

Articles referenced by this article (15)

Show 5 more references (10 of 15)

Citations & impact 

Impact metrics

34
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/27917323
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/27917323

Article citations

Go to all (34) article citations

Other citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NIAMS NIH HHS (2)