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Chromatin modifications and their function.

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Affiliations

  • 1. The Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB21QN, UK.
      Authors
    • Kouzarides T 1
    (1 author)

ORCIDs linked to this article

Cell, 01 Feb 2007, 128(4):693-705
https://doi.org/10.1016/j.cell.2007.02.005 PMID: 17320507 

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Abstract 

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight different classes have been characterized to date and many different sites have been identified for each class. Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA. In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited.

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Read article at publisher's site: https://doi.org/10.1016/j.cell.2007.02.005

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S0092867407001845/pdfUnpaywall

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