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Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.

Author information

Affiliations

  • 1. Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA.
      Authors
    • Lobo MK 1
    (1 author)

ORCIDs linked to this article

Nature Neuroscience, 14 Oct 2007, 10(11):1395-1397
https://doi.org/10.1038/nn1987 PMID: 17934457 

Abstract 

Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in instrumental conditioning in vivo. Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal.

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Read article at publisher's site: https://doi.org/10.1038/nn1987

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Funding 

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NICHD NIH HHS (1)

NIDA NIH HHS (2)