PIK3CA gene amplification in Japanese non-small cell lung cancer.

Lung Cancer (Amsterdam, Netherlands), 06 Aug 2007, 58(1):159-160
https://doi.org/10.1016/j.lungcan.2007.06.020 PMID: 17681398

Abstract

We have investigated 92 non-small cell lung cancer tissues and found 11 PIK3CA amplification. PIK3CA amplification incidence was significantly higher in male, smoker and squamous cell carcinoma patients. Among 11 patients with PIK3CA amplification, two patients harbored a PIK3CA mutation. There was significant difference in survival between the patients with PIK3CA normal copy number and the patients with PIK3CA amplification.

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References

Articles referenced by this article (13)

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Proteins in UniProt (Showing 5 of 12)

PI3K-ABD domain-containing protein(UniProt - A0A2P0XI22)
PI3K-ABD domain-containing protein(UniProt - A0A3G2C3N5)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(UniProt - P42336)
PI3K/PI4K catalytic domain-containing protein(UniProt - A0A8A2FPJ2)
PI3 kinase(UniProt - E5FF38)

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PIK3CA gene amplification in Japanese non-small cell lung cancer.

Abstract

Full text links

References

PIK3CA mutation status in Japanese lung cancer patients.

DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.

Comparative genomic hybridization and chromosomal instability in solid tumours.

Comparative genomic hybridization reveals complex genetic changes in primary breast cancer tumors and their cell lines.

Somatic mutation and gain of copy number of PIK3CA in human breast cancer.

Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma.

DNA gains in 3q occur frequently in squamous cell carcinoma of the lung, but not in adenocarcinoma.

Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway.

Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression.

Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay.

Citations & impact

Impact metrics

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.lungcan.2007.06.020

Article citations

Comprehensive Analysis of Clinically Relevant Copy Number Alterations (CNAs) Using a 523-Gene Next-Generation Sequencing Panel and NxClinical Software in Solid Tumors.

Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives.

Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions.

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds.

Brief Report: Prognostic Relevance of 3q Amplification in Squamous Cell Carcinoma of the Lung.

Data

Data that cites the article

Proteins in UniProt (Showing 5 of 12)

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