Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos.

Author information

Affiliations

  • 1. Department of Biochemistry, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
      Authors
    • Petruk S 1
    (1 author)

RNA Biology, 01 Jan 2007, 4(1):1-6
https://doi.org/10.4161/rna.4.1.4300 PMID: 17568198 

Abstract 

There is growing appreciation for the role of non-coding (nc) RNA in regulation of HOX genes of Drosophila. Our data suggest that current models for activation by ncRNA at the bithorax complex (BX-C) genes are mistaken. We propose that bxd and iab ncRNAs repress coding HOX genes Ultrabithorax and abdominal A, respectively, by transcriptional interference. It is not clear how regulation by non-coding RNAs is integrated with other regulatory mechanisms at HOX loci. We suggest that non-coding RNAs regulated by the trithorax group of epigenetic regulators have an early transient role in repression of HOX genes at the bithorax complex. Later, we propose that repression by HOX proteins, and members of the Polycomb group take over from repression by ncRNAs. We discuss emerging research questions in light of this model.

Full text links 

Read article at publisher's site: https://doi.org/10.4161/rna.4.1.4300

Read article for free, from open access legal sources, via Unpaywall: https://www.tandfonline.com/doi/pdf/10.4161/rna.4.1.4300?needAccess=trueUnpaywall

Citations & impact 

Impact metrics

16
Citations
Jump to Citations
1
Data citation
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/3369316
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/3369316

Article citations

Go to all (16) article citations

Other citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NCI NIH HHS (1)

NIGMS NIH HHS (1)