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Neuronal subtype specification in the cerebral cortex.

Author information

Affiliations

  • 1. MGH-HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
      Authors
    • Molyneaux BJ 1
    (1 author)

ORCIDs linked to this article

Nature reviews. Neuroscience, 01 Jun 2007, 8(6):427-437
https://doi.org/10.1038/nrn2151 PMID: 17514196 

Review

Abstract 

In recent years, tremendous progress has been made in understanding the mechanisms underlying the specification of projection neurons within the mammalian neocortex. New experimental approaches have made it possible to identify progenitors and study the lineage relationships of different neocortical projection neurons. An expanding set of genes with layer and neuronal subtype specificity have been identified within the neocortex, and their function during projection neuron development is starting to be elucidated. Here, we assess recent data regarding the nature of neocortical progenitors, review the roles of individual genes in projection neuron specification and discuss the implications for progenitor plasticity.

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Read article at publisher's site: https://doi.org/10.1038/nrn2151

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Funding 

Funders who supported this work.

NINDS NIH HHS (3)