PI3-kinase subunits are infrequent somatic targets in melanoma.

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References

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Genome-Scale DNA Methylation Analysis Identifies Repeat Element Alterations that Modulate the Genomic Stability of Melanocytic Nevi.
Muse ME, Bergman DT, Salas LA, Tom LN, Tan JM, Laino A, Lambie D, Sturm RA, Schaider H, Soyer HP, Christensen BC, Stark MS
J Invest Dermatol, 142(7):1893-1902.e7, 03 Dec 2021
Cited by: 8 articles | PMID: 34871578 | PMCID: PMC9163203
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A20 promotes melanoma progression via the activation of Akt pathway.
Ma J, Wang H, Guo S, Yi X, Zhao T, Liu Y, Shi Q, Gao T, Li C, Guo W
Cell Death Dis, 11(9):794, 23 Sep 2020
Cited by: 10 articles | PMID: 32968045 | PMCID: PMC7511359
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation.
Silva JM, Deuker MM, Baguley BC, McMahon M
Pigment Cell Melanoma Res, 30(3):353-367, 20 Apr 2017
Cited by: 9 articles | PMID: 28233937 | PMCID: PMC5411292
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The Conundrum of Genetic "Drivers" in Benign Conditions.
Kato S, Lippman SM, Flaherty KT, Kurzrock R
J Natl Cancer Inst, 108(8):djw036, 07 Apr 2016
Cited by: 57 articles | PMID: 27059373 | PMCID: PMC5017937
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The genomic landscape of cutaneous melanoma.
Zhang T, Dutton-Regester K, Brown KM, Hayward NK
Pigment Cell Melanoma Res, 29(3):266-283, 04 Mar 2016
Cited by: 92 articles | PMID: 26833684
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Nucleotide sequences in ENA

INSDC Project(ENA - PRJNA92269)

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NCI NIH HHS (1)

Grant ID: R33 CA95300
9 publications

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Abstract

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References

Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype.

Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization.

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.

Distinct sets of genetic alterations in melanoma.

Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.

Loss of heterozygosity for 10q22-10qter in malignant melanoma progression.

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

Citations & impact

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Citations of article over time

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Genome-Scale DNA Methylation Analysis Identifies Repeat Element Alterations that Modulate the Genomic Stability of Melanocytic Nevi.

A20 promotes melanoma progression via the activation of Akt pathway.

PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation.

The Conundrum of Genetic "Drivers" in Benign Conditions.

The genomic landscape of cutaneous melanoma.

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Nucleotide sequences in ENA

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PI3-kinase subunits are infrequent somatic targets in melanoma.

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