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Trypanosoma cruzi surface mucins: host-dependent coat diversity.

Author information

Affiliations

  • 1. Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (IIB-INTECH), Universidad Nacional de General San Martn-CONICET, San Martín (1650), Buenos Aires, Argentina.
      Authors
    • Buscaglia CA 1
    (1 author)

ORCIDs linked to this article

Nature reviews. Microbiology, 01 Mar 2006, 4(3):229-236
https://doi.org/10.1038/nrmicro1351 PMID: 16489349 

Review

Abstract 

The surface of the protozoan parasite Trypanosoma cruzi is covered in mucins, which contribute to parasite protection and to the establishment of a persistent infection. Their importance is highlighted by the fact that the approximately 850 mucin-encoding genes comprise approximately 1% of the parasite genome and approximately 6% of all predicted T. cruzi genes. The coordinate expression of a large repertoire of mucins containing variable regions in the mammal-dwelling stages of the T. cruzi life cycle suggests a possible strategy to thwart the host immune response. Here, we discuss the expression profiling of T. cruzi mucins, the mechanisms leading to the acquisition of mucin diversity and the possible consequences of a mosaic surface coat in the interplay between parasite and host.

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Read article at publisher's site: https://doi.org/10.1038/nrmicro1351

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