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Strategies for disease modification in Alzheimer's disease.

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Affiliations

  • 1. Amgen Incorporated, Department of Neuroscience, M/S 29-2-B, One Amgen Center Drive, Thousand Oaks, California 91320, USA.
      Authors
    • Citron M 1
    (1 author)

Nature reviews. Neuroscience, 01 Sep 2004, 5(9):677-685
https://doi.org/10.1038/nrn1495 PMID: 15322526 

Review

Abstract 

Treating Alzheimer's disease (AD) is the biggest unmet medical need in neurology. Current drugs improve symptoms, but do not have profound disease-modifying effects. Three main classes of disease-modification approaches can be defined: one that is broadly neurotrophic or neuroprotective, one that targets specific aspects of AD pathology, and one that is based on epidemiological observation. This review discusses all three approaches, with particular emphasis on anti-amyloid strategies - currently the most active area of investigation. The approaches that are reviewed include secretase inhibition, amyloid-beta aggregation inhibition, immunotherapy and strategies that might indirectly affect the amyloid pathway.

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Read article at publisher's site: https://doi.org/10.1038/nrn1495

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