Genomic imprinting: CTCF protects the boundaries.

Abstract

The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

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References

Articles referenced by this article (17)

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene.
Bell AC, Felsenfeld G
Nature, (6785):482-485 2000
MED: 10839546
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus.
Hark AT, Schoenherr CJ, Katz DJ, Ingram RS, Levorse JM, Tilghman SM
Nature, (6785):486-489 2000
MED: 10839547
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains.
Pant V, Mariano P, Kanduri C, Mattsson A, Lobanenkov V, Heuchel R, Ohlsson R
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CTCF maintains differential methylation at the Igf2/H19 locus.
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CTCF elements direct allele-specific undermethylation at the imprinted H19 locus
Rand
Curr. Biol. 2004
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Science, (5655):238-240 2004
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Human IGF2 Gene Epigenetic and Transcriptional Regulation: At the Core of Developmental Growth and Tumorigenic Behavior.
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Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.
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Intrachromosomal Looping and Histone K27 Methylation Coordinately Regulates the lncRNA H19-Fetal Mitogen IGF2 Imprinting Cluster in the Decidual Microenvironment of Early Pregnancy.
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Chromatin Remodelers in the 3D Nuclear Compartment.
Magaña-Acosta M, Valadez-Graham V
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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.
Ragazzini R, Pérez-Palacios R, Baymaz IH, Diop S, Ancelin K, Zielinski D, Michaud A, Givelet M, Borsos M, Aflaki S, Legoix P, Jansen PWTC, Servant N, Torres-Padilla ME, Bourc'his D, Fouchet P, Vermeulen M, Margueron R
Nat Commun, 10(1):3858, 26 Aug 2019
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Abstract

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References

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene.

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus.

The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains.

CTCF maintains differential methylation at the Igf2/H19 locus.

CTCF elements direct allele-specific undermethylation at the imprinted H19 locus

Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting.

Dividing the empire: boundary chromatin elements delimit the territory of enhancers.

Stopped at the border: boundaries and insulators.

Characterization of the chicken beta-globin insulator.

Regulatory mechanisms at the mouse Igf2/H19 locus.

Citations & impact

Impact metrics

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.cub.2004.03.026

Article citations

Human IGF2 Gene Epigenetic and Transcriptional Regulation: At the Core of Developmental Growth and Tumorigenic Behavior.

Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.

Intrachromosomal Looping and Histone K27 Methylation Coordinately Regulates the lncRNA H19-Fetal Mitogen IGF2 Imprinting Cluster in the Decidual Microenvironment of Early Pregnancy.

Chromatin Remodelers in the 3D Nuclear Compartment.

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

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Genomic imprinting: CTCF protects the boundaries.

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CTCF elements direct allele-specific undermethylation at the imprinted H19 locus

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