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Nucleosome arrays reveal the two-start organization of the chromatin fiber.

Author information

Affiliations

  • 1. Eidgenössische Technische Hochschule (ETH) Zürich, Institute for Molecular Biology and Biophysics, ETH-Hönggerberg, CH-8093 Zürich, Switzerland.
      Authors
    • Dorigo B 1
    (1 author)

ORCIDs linked to this article

Science, 01 Nov 2004, 306(5701):1571-1573
https://doi.org/10.1126/science.1103124 PMID: 15567867 

A comment on this article appears in "Molecular biology. A higher order of silence." Science. 2004 Nov 26;306(5701):1484-5.

Abstract 

Chromatin folding determines the accessibility of DNA constituting eukaryotic genomes and consequently is profoundly important in the mechanisms of nuclear processes such as gene regulation. Nucleosome arrays compact to form a 30-nanometer chromatin fiber of hitherto disputed structure. Two competing classes of models have been proposed in which nucleosomes are either arranged linearly in a one-start higher order helix or zigzag back and forth in a two-start helix. We analyzed compacted nucleosome arrays stabilized by introduction of disulfide cross-links and show that the chromatin fiber comprises two stacks of nucleosomes in accord with the two-start model.

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Read article at publisher's site: https://doi.org/10.1126/science.1103124

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