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Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis.

Author information

Affiliations

  • 1. Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
      Authors
    • Yang L 1
    (1 author)

ORCIDs linked to this article

Cancer Cell, 01 Oct 2004, 6(4):409-421
https://doi.org/10.1016/j.ccr.2004.08.031 PMID: 15488763 

Abstract 

We demonstrate a novel tumor-promoting role of myeloid immune suppressor Gr+CD11b+ cells, which are evident in cancer patients and tumor-bearing animals. These cells constitute approximately 5% of total cells in tumors. Tumors coinjected with Gr+CD11b+ cells exhibited increased vascular density, vascular maturation, and decreased necrosis. These immune cells produce high levels of MMP9. Deletion of MMP9 in these cells completely abolishes their tumor-promoting ability. Gr+CD11b+ cells were also found to directly incorporate into tumor endothelium. Consistent with this observation, Gr+CD11b+ cells acquire endothelial cell (EC) properties in tumor microenvironment and proangiogenic culture conditions. Our data provide evidence that Gr+CD11b+ cells of immune origin induced by tumors directly contribute to tumor growth and vascularization by producing MMP9 and differentiating into ECs.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.ccr.2004.08.031

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S1535610804002703/pdfUnpaywall

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NCI NIH HHS (6)