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Association of tau gene polymorphism with Parkinson's disease.

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Affiliations

  • 1. Clinica Neurologica, Università di Catanzaro, Via Campanella, Catanzaro, Italy.
      Authors
    • Zappia M 1
    (1 author)

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Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 01 Oct 2003, 24(3):223-224
https://doi.org/10.1007/s10072-003-0141-z PMID: 14600827 

Abstract 

We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and 10 of the tau gene in 300 patients with Parkinson's disease (PD) and in 197 normal controls. The A3 allele was more frequent in cases than in controls (30% versus 16%, p<0.001), and individuals carrying at least one A3 allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95% confidence interval 1.81-4.29). No significant differences were found between patients by considering the age at onset and the presence of family history or dementia. Our findings suggest a possible involvement of the tau gene in the pathogenesis of PD.

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Read article at publisher's site: https://doi.org/10.1007/s10072-003-0141-z

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