Protein tyrosine phosphatase 1B inhibitors for diabetes.

Abstract

Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need for new agents to treat these disease states. Resistance to the hormones insulin and leptin are hallmarks of both type 2 diabetes and obesity. Drugs that can ameliorate this resistance should be effective in treating type 2 diabetes and possibly obesity. Protein tyrosine phosphatase 1B (PTP1B) is thought to function as a negative regulator of insulin and leptin signal transduction. This article reviews PTP1B as a novel target for type 2 diabetes, and looks at the challenges in developing small-molecule inhibitors of this phosphatase.

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References

Articles referenced by this article (95)

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Computer-Aided Strategy on 5-(Substituted benzylidene) Thiazolidine-2,4-Diones to Develop New and Potent PTP1B Inhibitors: QSAR Modeling, Molecular Docking, Molecular Dynamics, PASS Predictions, and DFT Investigations.
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Go to all (305) article citations

Search life-sciences literature (45,094,167 articles, preprints and more)

Affiliations

Abstract

Full text links

References

Global and societal implications of the diabetes epidemic.

Prevalence of impaired glucose tolerance among children and adolescents with marked obesity.

Childhood obesity and a diabetes epidemic.

The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study.

The dysmetabolic syndrome.

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity.

Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development.

Clinical characterization of insulin secretion as the basis for genetic analyses.

Uusitupa, M. et al. The Finnish Diabetes Prevention Study. Br. J. Nutr. 83 (Suppl. 1), S137–S142 (2000).

The Diabetes Prevention Study Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393–403 (2002).

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Mapping spatial organization and genetic cell-state regulators to target immune evasion in ovarian cancer.

A facile strategy for the construction of a phage display cyclic peptide library for the selection of functional macrocycles.

Design, synthesis, inhibitory activity, and molecular simulations study for d-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus.

Analogues of Dihydroflavonol and Flavone as Protein Tyrosine Phosphatase 1B Inhibitors from the Leaves of Artocarpus elasticus.

Computer-Aided Strategy on 5-(Substituted benzylidene) Thiazolidine-2,4-Diones to Develop New and Potent PTP1B Inhibitors: QSAR Modeling, Molecular Docking, Molecular Dynamics, PASS Predictions, and DFT Investigations.

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Protein tyrosine phosphatase 1B inhibitors for diabetes.

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Abstract

Full text links

References

Uusitupa, M. et al. The Finnish Diabetes Prevention Study. Br. J. Nutr. 83 (Suppl. 1), S137–S142 (2000).

The Diabetes Prevention Study Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393–403 (2002).

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