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The evolution of signalling pathways in animal development.

Author information

Affiliations

  • 1. Department of Evolutionary Biology, Max-Planck-nstitut für Entwicklungsbiologie, Spemannstrasse 37-39, D-72076 Tübingen, Germany.
      Authors
    • Pires-daSilva A 1
    (1 author)

ORCIDs linked to this article

Nature reviews. Genetics, 01 Jan 2003, 4(1):39-49
https://doi.org/10.1038/nrg977 PMID: 12509752 

Review

Abstract 

Despite the bewildering number of cell types and patterns found in the animal kingdom, only a few signalling pathways are required to generate them. Most cell-cell interactions during embryonic development involve the Hedgehog, Wnt, transforming growth factor-beta, receptor tyrosine kinase, Notch, JAK/STAT and nuclear hormone pathways. Looking at how these pathways evolved might provide insights into how a few signalling pathways can generate so much cellular and morphological diversity during the development of individual organisms and the evolution of animal body plans.

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Read article at publisher's site: https://doi.org/10.1038/nrg977

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