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Maintenance of serological memory by polyclonal activation of human memory B cells.

Author information

Affiliations

  • 1. Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland.
      Authors
    • Bernasconi NL 1
    (1 author)

Science, 01 Dec 2002, 298(5601):2199-2202
https://doi.org/10.1126/science.1076071 PMID: 12481138 

Abstract 

Production of antibodies can last for a lifetime, through mechanisms that remain poorly understood. Here, we show that human memory B lymphocytes proliferate and differentiate into plasma cells in response to polyclonal stimuli, such as bystander T cell help and CpG DNA. Furthermore, plasma cells secreting antibodies to recall antigens are produced in vivo at levels proportional to the frequency of specific memory B cells, even several years after antigenic stimulation. Although antigen boosting leads to a transient increase in specific antibody levels, ongoing polyclonal activation of memory B cells offers a means to maintain serological memory for a human lifetime.

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Read article at publisher's site: https://doi.org/10.1126/science.1076071

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