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What does 'chromatin remodeling' mean?

Author information

Affiliations

  • 1. Dept of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
      Authors
    • Aalfs JD 1
    (1 author)

Trends in Biochemical Sciences, 01 Nov 2000, 25(11):548-555
https://doi.org/10.1016/s0968-0004(00)01689-3 PMID: 11084367 

Review

Abstract 

The regulated alteration of chromatin structure, termed 'chromatin remodeling', can be accomplished by covalent modification of histones or by the action of ATP-dependent remodeling complexes. A variety of mechanisms can be used to remodel chromatin; some act locally on a single nucleosome and others act more broadly. It is critical to establish a direct connection between the remodeling events observed in vivo and the mechanistic capabilities of remodeling complexes in vitro.

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Read article at publisher's site: https://doi.org/10.1016/s0968-0004(00)01689-3

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