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Melanopsin in cells of origin of the retinohypothalamic tract.

Author information

Affiliations

  • 1. Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
      Authors
    • Gooley JJ 1
    (1 author)

Nature Neuroscience, 01 Dec 2001, 4(12):1165
https://doi.org/10.1038/nn768 PMID: 11713469 

Abstract 

All known eukaryotic organisms exhibit physiological and behavioral rhythms termed circadian rhythms that cycle with a near-24-hour period; in mammals, light is the most potent stimulus for entraining endogenous rhythms to the daily light cycle. Photic information is transmitted via the retinohypothalamic tract (RHT) to the suprachiasmatic nucleus (SCN) in the hypothalamus, where circadian rhythms are generated, but the retinal photopigment that mediates circadian entrainment has remained elusive. Here we show that most retinal ganglion cells (RGCs) that project to the SCN express the photopigment melanopsin.

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Read article at publisher's site: https://doi.org/10.1038/nn768

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Funding 

Funders who supported this work.

NHLBI NIH HHS (2)

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