Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

IL-15 expression at human endometrium and decidua.

Author information

Affiliations

  • 1. Department of Obstetrics and Gynecology and Dynamic Pathology Research Institute, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
      Authors
    • Kitaya K 1
    (1 author)

Biology of Reproduction, 01 Sep 2000, 63(3):683-687
https://doi.org/10.1095/biolreprod63.3.683 PMID: 10952908 

Abstract 

A large number of natural killer (NK) cells appear in human uterine mucosa during the secretory phase and first trimester pregnancy. We investigated the expression of interleukin (IL)-15, a possible stimulator for these NK cells, in human endometrium and first trimester decidua. Semiquantitative reverse transcriptase-polymerase chain reaction revealed that IL-15 mRNA expression was stronger during the secretory phase and first trimester pregnancy than during the proliferative phase. Immunohistochemistry revealed that immunoreactivity for anti-IL-15 was higher during the secretory phase than it was during the proliferative phase. This was prominent in the perivascular stromal cells around invading spiral arteries during the mid- to late-secretory phase. In first trimester decidua, endothelial cells were also stained as strongly as stromal cells. A membrane-bound IL-15 molecule was detected on the surface of first trimester decidual cells by flow cytometry. Progesterone stimulated the release of soluble IL-15 in the supernatant of cultured decidual cells. These results suggest that IL-15 expression in human uterine mucosa corresponds to the fluctuation of uterine NK cells and that its production is hormonally controlled, especially by progesterone.

Full text links 

Read article at publisher's site: https://doi.org/10.1095/biolreprod63.3.683

Read article for free, from open access legal sources, via Unpaywall: https://academic.oup.com/biolreprod/article-pdf/63/3/683/10592691/biolreprod0683.pdfUnpaywall

References 

Articles referenced by this article (42)

Show 10 more references (10 of 42)

Citations & impact 

Impact metrics

113
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/42029696
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/42029696

Article citations

Go to all (113) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.