Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

Author information

Affiliations

  • 1. Department of Microbiology and Immunology and The Cancer Research Institute, University of California, San Francisco 94143, USA.
      Authors
    • Cerwenka A 1
    (1 author)

ORCIDs linked to this article

Immunity, 01 Jun 2000, 12(6):721-727
https://doi.org/10.1016/s1074-7613(00)80222-8 PMID: 10894171 

Abstract 

Here we describe a family of GPI-anchored cell surface proteins that function as ligands for the mouse activating NKG2D receptor. These molecules are encoded by the retinoic acid early inducible (RAE-1) and H60 minor histocompatibility antigen genes on mouse chromosome 10 and show weak homology with MHC class I. Expression of the NKG2D ligands is low or absent on normal, adult tissues; however, they are constitutively expressed on some tumors and upregulated by retinoic acid. Ectopic expression of RAE-1 and H60 confers target susceptibility to NK cell attack. These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/s1074-7613(00)80222-8

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S1074761300802228/pdfUnpaywall

References 

Articles referenced by this article (32)

Show 10 more references (10 of 32)

Citations & impact 

Impact metrics

443
Citations
Jump to Citations
18
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/3515588
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/3515588

Article citations

Go to all (443) article citations

Other citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.