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Scavenger receptor BI and cholesterol trafficking.

Author information

Affiliations

  • 1. Department of Pharmacological Sciences, University Medical Centre, State University of New York at Stony Brook, 11794, USA.
      Authors
    • Williams DL 1
    (1 author)

ORCIDs linked to this article

Current Opinion in Lipidology, 01 Aug 1999, 10(4):329-339
https://doi.org/10.1097/00041433-199908000-00007 PMID: 10482136 

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Abstract 

Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.

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Read article at publisher's site: https://doi.org/10.1097/00041433-199908000-00007

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Funding 

Funders who supported this work.

NHLBI NIH HHS (3)