Article

PQuad: Visualization of Predicted Peptides and Proteins

Authors:

Susan L. Havre,

Mudita Singhal,

Deborah A. Payne,

Bobbie-Jo M. Webb-RobertsonAuthors Info & Claims

VIS '04: Proceedings of the conference on Visualization '04

Pages 473 - 480

https://doi.org/10.1109/VISUAL.2004.82

Published: 10 October 2004 Publication History

Abstract

New high-throughput proteomic techniques generate data faster than biologists can analyze it. Hidden within this massive and complex data are answers to basic questions about how cells function. The data afford an opportunity to take a global or systems approach studying whole proteomes comprising all the proteins in an organism. However, the tremendous size and complexity of the high-throughput data make it difficult to process and interpret. Existing tools for studying a few proteins at a time are not suitable for global analysis. Visualization provides powerful analysis capabilities for enormous, complex data at multiple resolutions. We developed a novel interactive visualization tool, PQuad, for the visual analysis of proteins and peptides identified from high-throughput data on biological samples. PQuad depicts the peptides in the context of their source protein and DNA, thereby integrating proteomic and genomic information. A wrapped line metaphor is applied across key resolutions of the data, from a compressed view of an entire chromosome to the actual nucleotide sequence. PQuad provides a difference visualization for comparing peptides from samples prepared under different experimental conditions. We describe the requirements for such a visual analysis tool, the design decisions, and the novel aspects of PQuad.

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Cited By

Havre SWebb-Robertson BShah APosse CGopalan BBrockman F(2005)Bioinformatic Insights from Metagenomics through VisualizationProceedings of the 2005 IEEE Computational Systems Bioinformatics Conference10.1109/CSB.2005.19(341-350)Online publication date: 8-Aug-2005
https://dl.acm.org/doi/10.1109/CSB.2005.19

PQuad: Visualization of Predicted Peptides and Proteins
1. Applied computing
  1. Life and medical sciences

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Published In

cover image ACM Conferences

VIS '04: Proceedings of the conference on Visualization '04

October 2004

667 pages

ISBN:0780387880

Sponsors

SIGGRAPH: ACM Special Interest Group on Computer Graphics and Interactive Techniques

Publisher

IEEE Computer Society

United States

Publication History

Published: 10 October 2004

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Cited By

Havre SWebb-Robertson BShah APosse CGopalan BBrockman F(2005)Bioinformatic Insights from Metagenomics through VisualizationProceedings of the 2005 IEEE Computational Systems Bioinformatics Conference10.1109/CSB.2005.19(341-350)Online publication date: 8-Aug-2005
https://dl.acm.org/doi/10.1109/CSB.2005.19

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