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A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

Nature volume 320, pages 415–421 (1986)Cite this article

Abstract

A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5′ ▵gag-kit-▵pol-▵env 3′ and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus.

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Author information

Author notes

  1. John E. Murphy

    Present address: Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA

  2. Lynn Lederman

    Present address: Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, 01545, USA

  3. Harry W. Snyder Jr

    Present address: Pacific Northwest Research Foundation, Seattle, Washington, 98104, USA

  4. Patricia C. George

    Present address: Cornell University Medical School, New York, New York, 10021, USA

  5. David Brodeur

    Present address: Duke University Medical School, Durham, North Carolina, 27710, USA

Authors and Affiliations

  1. Laboratory of Molecular Oncology, Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York, 10221, USA

    Peter Besmer, John E. Murphy, Patricia C. George, Feihua Qiu & Peter J. Bergold

  2. Laboratory of Viral Oncology, Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York, 10221, USA

    Lynn Lederman & Harry W. Snyder Jr

  3. Laboratory of Veterinary Oncology, Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York, 10221, USA

    Evelyn E. Zuckerman & William D. Hardy

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Besmer, P., Murphy, J., George, P. et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 320, 415–421 (1986). https://doi.org/10.1038/320415a0

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