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Measurement of $^{12}$C Fragmentation Cross Sections on C, O, and H in the Energy Range of Interest for Particle Therapy Applications / Mattei, I ; Alexandrov, A ; Alunni Solestizi, L ; Ambrosi, G ; Argiro, S ; Bartosik, N ; Battistoni, G ; Belcari, N ; Biondi, S ; Bisogni, M G et al.
In a carbon ion treatment the nuclear fragmentation of both target and beam projectiles impacts on the dose released on the tumor and on the surrounding healthy tissues. Carbon ion fragmentation occurring inside the patient body has to be studied in order to take into account this contribution. [...]
2020 - 14 p. - Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 269-282

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Ion charge separation with new generation of nuclear emulsion films / Montesi, M.C. (Naples U. ; INFN, Naples) ; Lauria, A. (Naples U. ; INFN, Naples) ; Alexandrov, A. (INFN, Naples ; Naples U. ; Natl. U. Sci. Tech., Moscow ; Lebedev Inst.) ; Solestizi, L. Alunni (INFN, Perugia ; Perugia U.) ; Giovanni, Ambrosi (INFN, Perugia) ; Argirò, S. (Turin U. ; INFN, Turin) ; Diaz, R. (Havana, CEADEN) ; Bartosik, N. (INFN, Turin) ; Battistoni, G. (INFN, Milan) ; Belcari, N. (Pisa U. ; INFN, Pisa) et al.
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel and in the volume surrounding the tumor. [...]
2019 - 8 p. - Published in : Open Physics 17 (2019) 233-240 Fulltext: PDF;

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The FOOT FragmentatiOn Of Target Experiment / Alexandrov, Andrey (INFN, Naples) ; Alpat, Behcet (INFN, Perugia) ; Ambrosi, Giovanni (INFN, Perugia) ; Argirò, Stefano (Turin U. ; INFN, Turin) ; Battistoni, Giuseppe (INFN, Milan) ; Bisogni, Maria Giuseppina (Pisa U. ; INFN, Pisa) ; Belcari, Nicola (Pisa U. ; INFN, Pisa) ; Biondi, Silvia (INFN, Bologna ; Bologna U.) ; Bruni, Graziano (INFN, Bologna) ; Camarlinghi, Niccolò (Pisa U. ; INFN, Pisa) et al.
In proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an un-wanted and undetermined increase of normal tissues complications probability may occur. [...]
Geneva : CERN, 2019 - 8 p. - Published in : CERN Proc.: 1 (2019) , pp. 305-312 Fulltext: PDF;
In : 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italy, 11 - 15 Jun 2018, pp.305-312

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iMPACT: An Innovative Tracker and Calorimeter for Proton Computed Tomography / Mattiazzo, Serena (Padua U. ; TIFPA-INFN, Trento) ; Baruffaldi, Filippo (Padua U.) ; Bisello, Dario (Padua U. ; TIFPA-INFN, Trento) ; Di Ruzza, Benedetto (Bari Polytechnic) ; Giubilato, Piero (Padua U. ; TIFPA-INFN, Trento) ; Iuppa, Roberto (Trento U. ; TIFPA-INFN, Trento) ; La Tessa, Chiara (Trento U. ; TIFPA-INFN, Trento) ; Pantano, Devis (Padua U. ; TIFPA-INFN, Trento) ; Pozzobon, Nicola (Padua U. ; TIFPA-INFN, Trento) ; Ricci, Ester (Trento U. ; TIFPA-INFN, Trento) et al.
This contribution describes the first results obtained within the iMPACT project, which aims to build a novel proton computed-tomography (pCT) scanner for protons of energy up to 230 MeV, as used in hadron therapy. The iMPACT pCT scanner will improve the current state-of-the-art in proton tracking at all levels: speed, spatial resolution, material budget, and cost. [...]
2018 - 8 p. - Published in : IEEE Trans. Rad. Plasma Med. Sci. 2 (2018) 345-352

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Measurement of charged particle yields from therapeutic beams in view of the design of an innovative hadrontherapy dose monitor / Battistoni, G (INFN, Milan) ; Bellini, F (Rome U. ; INFN, Rome) ; Bini, F (U. Rome La Sapienza (main)) ; Collamati, F (Rome U. ; INFN, Rome) ; Collini, F (INFN, Milan) ; De Lucia, E (Frascati) ; Durante, M (Darmstadt, GSI) ; Faccini, R (Rome U. ; INFN, Rome) ; Ferroni, F (Rome U. ; INFN, Rome) ; Frallicciardi, P M (Enrico Fermi Ctr., Rome) et al.
Particle Therapy (PT) is an emerging technique, which makes use of charged particles to efficiently cure different kinds of solid tumors. The high precision in the hadrons dose deposition requires an accurate monitoring to prevent the risk of under-dosage of the cancer region or of over-dosage of healthy tissues. [...]
2015 - Published in : JINST 10 (2015) C02032 IOP Open Access article: PDF;

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Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u12Cbeam / Piersanti, L (Frascati ; U. Rome La Sapienza (main)) ; Bellini, F (Rome U. ; INFN, Rome) ; Bini, FU. Rome La Sapienza (main) ; Collamati, F (Rome U. ; INFN, Rome) ; De Lucia, E (Frascati) ; Durante, M (Darmstadt, GSI) ; Faccini, R (Rome U. ; INFN, Rome) ; Ferroni, F (Rome U. ; INFN, Rome) ; Fiore, S (Rome U.) ; Iarocci, E (Frascati ; U. Rome La Sapienza (main)) et al.
The radiation used in hadrontherapy treatments interacts with the patient body producing secondary particles, either neutral or charged, that can be used for dose and Bragg peak monitoring and to provide a fast feedback on the treatment plans. Recent results obtained from the authors on simplified setups (mono-energetic primary beams interacting with homogeneous tissue like target) have already indicated the correlation that exists between the flux of these secondaries coming from the target (e.g. [...]
2014 - 16. - Published in : Phys. Med. Biol. 59 (2014) 1857-1872

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