002803908 001__ 2803908
002803908 003__ SzGeCERN
002803908 005__ 20220426202957.0
002803908 0247_ $$2DOI$$a10.3389/fmed.2021.693682
002803908 0248_ $$aoai:cds.cern.ch:2803908$$pcerncds:FULLTEXT$$pcerncds:CERN:FULLTEXT$$pcerncds:CERN
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002803908 035__ $$9Inspire$$a2036504
002803908 041__ $$aeng
002803908 100__ $$aDuchemin, Charlotte$$uCERN$$uLeuven U.
002803908 245__ $$9submitter$$aCERN-MEDICIS: A Review Since Commissioning in 2017
002803908 260__ $$c2021
002803908 300__ $$a11 p
002803908 520__ $$9submitter$$aThe CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. The facility has been built as an extension of the ISOLDE (Isotope Separator On Line DEvice) facility at CERN. Handling of open radioisotope sources is made possible thanks to its Radiological Controlled Area and laboratory. Targets are being irradiated by the 1.4 GeV proton beam delivered by the CERN Proton Synchrotron Booster (PSB) on a station placed between the High Resolution Separator (HRS) ISOLDE target station and its beam dump. Irradiated target materials are also received from external institutes to undergo mass separation at CERN-MEDICIS. All targets are handled via a remote handling system and exploited on a dedicated isotope separator beamline. To allow for the release and collection of a specific radionuclide of medical interest, each target is heated to temperatures of up to 2,300°C. The created ions are extracted and accelerated to an energy up to 60 kV, and the beam steered through an off-line sector field magnet mass separator. This is followed by the extraction of the radionuclide of interest through mass separation and its subsequent implantation into a collection foil. In addition, the MELISSA (MEDICIS Laser Ion Source Setup At CERN) laser laboratory, in service since April 2019, helps to increase the separation efficiency and the selectivity. After collection, the implanted radionuclides are dispatched to the biomedical research centers, participating in the CERN-MEDICIS collaboration, for Research & Development in imaging or treatment. Since its commissioning, the CERN-MEDICIS facility has provided its partner institutes with non-conventional medical radionuclides such as Tb-149, Tb-152, Tb-155, Sm-153, Tm-165, Tm-167, Er-169, Yb-175, and Ac-225 with a high specific activity. This article provides a review of the achievements and milestones of CERN-MEDICIS since it has produced its first radioactive isotope in December 2017, with a special focus on its most recent operation in 2020.
002803908 540__ $$3publication$$aCC BY 4.0$$uhttp://creativecommons.org/licenses/by/4.0/
002803908 542__ $$3publication$$dThe authors$$f© 2021 Duchemin, Ramos, Stora, Ahmed, Aubert, Audouin,
Barbero, Barozier, Bernardes, Bertreix, Boscher, Bruchertseifer, Catherall, Chevallay,
Christodoulou, Chrysalidis, Cocolios, Comte, Crepieux, Deschamps, Dockx,
Dorsival, Fedosseev, Fernier, Formento-Cavaier, El Idrissi, Ivanov, Gadelshin,
Gilardoni, Grenard, Haddad, Heinke, Juif, Khalid, Khan, Köster, Lambert, Lilli,
Lunghi, Marsh, Palenzuela, Martins, Marzari, Menaa, Michel, Munos, Pozzi,
Riccardi, Riegert, Riggaz, Rinchet, Rothe, Russell, Saury, Schneider, Stegemann,
Talip, Theis, Thiboud, van der Meulen, van Stenis, Vincke, Vollaire, Vuong, Webster,
Wendt, Wilkins and the CERN-MEDICIS collaboration.$$g2021
002803908 65017 $$2SzGeCERN$$aNuclear Physics - Experiment
002803908 690C_ $$aARTICLE
002803908 690C_ $$aCERN
002803908 693__ $$aCERN MEDICIS
002803908 700__ $$aRamos, Joao P$$uCERN$$uLeuven U.
002803908 700__ $$aStora, Thierry$$uCERN
002803908 700__ $$aAhmed, Essraa$$uLeuven U.
002803908 700__ $$aAubert, Elodie$$uCERN
002803908 700__ $$aAudouin, Nadia$$uGIP ARRONAX
002803908 700__ $$aBarbero, Ermanno$$uCERN
002803908 700__ $$aBarozier, Vincent$$uCERN
002803908 700__ $$aBernardes, Ana-Paula$$uCERN
002803908 700__ $$aBertreix, Philippe$$uCERN
002803908 700__ $$aBoscher, Aurore$$uCERN
002803908 700__ $$aBruchertseifer, Frank$$uUnlisted, DE
002803908 700__ $$aCatherall, Richard$$uCERN
002803908 700__ $$aChevallay, Eric$$uCERN
002803908 700__ $$aChristodoulou, Pinelopi$$uCERN
002803908 700__ $$aChrysalidis, Katerina$$uCERN
002803908 700__ $$aCocolios, Thomas E$$uLeuven U.
002803908 700__ $$aComte, Jeremie$$uCERN
002803908 700__ $$aCrepieux, Bernard$$uCERN
002803908 700__ $$aDeschamps, Matthieu$$uCERN
002803908 700__ $$aDockx, Kristof$$uLeuven U.
002803908 700__ $$aDorsival, Alexandre$$uCERN
002803908 700__ $$aFedosseev, Valentin N$$uCERN
002803908 700__ $$aFernier, Pascal$$uCERN
002803908 700__ $$aFormento-Cavaier, Robert$$uCERN$$uGIP ARRONAX
002803908 700__ $$aEl Idrissi, Safouane$$uCERN
002803908 700__ $$aIvanov, Peter$$uTeddington, Natl. Phys. Lab
002803908 700__ $$aGadelshin, Vadim M$$uCERN$$uMainz U.
002803908 700__ $$aGilardoni, Simone$$uCERN
002803908 700__ $$aGrenard, Jean-Louis$$uCERN
002803908 700__ $$aHaddad, Ferid$$uGIP ARRONAX
002803908 700__ $$aHeinke, Reinhard$$uCERN$$uLeuven U.
002803908 700__ $$aJuif, Benjamin$$uCERN
002803908 700__ $$aKhalid, Umair$$uCERN$$uIST, Islamabad
002803908 700__ $$aKhan, Moazam$$uCERN$$uIST, Islamabad
002803908 700__ $$aKöster, Ulli$$uLaue-Langevin Inst.
002803908 700__ $$aLambert, Laura$$uCERN
002803908 700__ $$aLilli, G$$uCERN
002803908 700__ $$aLunghi, Giacomo$$uCERN
002803908 700__ $$aMarsh, Bruce A$$uCERN
002803908 700__ $$aMartinez Palenzuela, Yisel$$uLeuven U.
002803908 700__ $$aMartins, Renata$$uCERN
002803908 700__ $$aMarzari, Stefano$$uCERN
002803908 700__ $$aMenaa, Nabil$$uCERN
002803908 700__ $$aMichel, Nathalie$$uGIP ARRONAX
002803908 700__ $$aMunos, Maxime$$uCERN
002803908 700__ $$aPozzi, Fabio$$uCERN
002803908 700__ $$aRiccardi, Francesco$$uCERN
002803908 700__ $$aRiegert, Julien$$uCERN
002803908 700__ $$aRiggaz, Nicolas$$uCERN
002803908 700__ $$aRinchet, Jean-Yves$$uCERN
002803908 700__ $$aRothe, Sebastian$$uCERN
002803908 700__ $$aRussell, Ben$$uTeddington, Natl. Phys. Lab
002803908 700__ $$aSaury, Christelle$$uCERN
002803908 700__ $$aSchneider, Thomas$$uCERN
002803908 700__ $$aStegemann, Simon$$uCERN$$uLeuven U.
002803908 700__ $$aTalip, Zeynep$$uPSI, Villigen
002803908 700__ $$aTheis, Christian$$uCERN
002803908 700__ $$aThiboud, Julien$$uCERN
002803908 700__ $$avan der Meulen, Nicholas P$$uPSI, Villigen
002803908 700__ $$avan Stenis, Miranda$$uCERN
002803908 700__ $$aVincke, Heinz$$uCERN
002803908 700__ $$aVollaire, Joachim$$uCERN
002803908 700__ $$aVuong, Nhat-Tan$$uCERN
002803908 700__ $$aWebster, Benjamin$$uTeddington, Natl. Phys. Lab
002803908 700__ $$aWendt, Klaus$$uMainz U.
002803908 700__ $$aWilkins, Shane G$$uCERN
002803908 710__ $$gMEDICIS Collaboration
002803908 773__ $$c693682$$pFrontiers in Medicine$$v8$$y2021
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