| Published Articles | |
| Title | Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN |
| Author(s) | Webster, Ben (Teddington, Natl. Phys. Lab ; Surrey U.) ; Ivanov, Peter (Teddington, Natl. Phys. Lab) ; Russell, Ben (Teddington, Natl. Phys. Lab) ; Collins, Sean (Teddington, Natl. Phys. Lab) ; Stora, Thierry (CERN) ; Ramos, Joao Pedro (CERN ; Leuven U.) ; Köster, Ulli (Laue-Langevin Inst.) ; Robinson, Andrew Paul (Teddington, Natl. Phys. Lab ; Manchester U.) ; Read, David (Teddington, Natl. Phys. Lab ; Surrey U.) |
| Publication | 2019 |
| In: | Sci. Rep. 9 (2019) 10884 |
| DOI | 10.1038/s41598-019-47463-3 |
| Abstract | Four terbium radioisotopes ($^{149, 152, 155, 161}$Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive$^{139}$Ce$^{16}$O and also zinc or gold, depending on the catcher foil used. A method using ion-exchange and extraction chromatography resins in two column separation steps has been developed to isolate$^{155}$Tb with a chemical yield of ≥95% and radionuclidic purity ≥99.9%. Conversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is presented. The resulting$^{155}$Tb preparations are suitable for the determination of absolute activity, SPECT phantom imaging studies and pre-clinical trials. |
| Copyright/License | Publication: © 2019-2024 The authors |
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Record creato 2019-08-23, modificato l'ultima volta il 2019-08-23